Do not take mirtazapine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Side EffectsMirtazapine decreases cortisol secretion by the adrenal glands but has not actually panned out as treatment for Cushing syndrome, where excess adrenal steroids are produced by the adrenal glands. Mirtazapine Remeron Remeron Organon NV, The Netherlands is an antidepressant with unique mechanism of action that has similar or superior efficacy to TCAs and SSRIs in moderate-to-severe depression. What other drugs will affect mirtazapine? apotheke mirtazapine Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by mirtazapine. The only drug overdose death reported while taking REMERON was in combination with amitriptyline and chlorprothixene in non-US clinical study. Alcohol The impairment of cognitive and motor skills produced by REMERON has been shown to be additive with those produced by alcohol.