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For complete information about this product or your specific health needs, ask your health care professional. Also used to replace medrol mit mastercard steroids in conditions of adrenal insufficiency low production of needed steroids produced by the adrenal glands. If you have been using Medrol for long time, the dose should be reduced gradually. Acting primarily through the hypothalamus fall in free cortisol stimulates the pituitary gland to produce increasing amounts of corticotropin ACTH while rise in free cortisol inhibits ACTH secretion. Persons who are on corticosteroids should be warned to avoid exposure to chicken pox or measles.